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The trispecific antibody was also recently tested on acute myeloid leukemia cell lines and patients (78)

"Pharmaceuticals go for it," she said

To obtain the specific labeling patterns, intracellular metabolites were extracted and analyzed using GC/MS to determine multiple ion detections (MIDs) (corrected for natural isotope abundance), which reflect relative metabolic fluxes 28

Macrophages detect these apoptotic cells using specific efferocytic receptors, such as Mer tyrosine kinase (MERTK) and T-cell immunoglobulin and mucin domain containing-4 (TIM-4), which recognize PS directly or indirectly through bridging molecules like Growth Arrest-specific gene 6 (Gas6) and Protein S [24, 30]