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Glucose is mainly converted into lactate (glycolysis), whereas glutamine is converted into glutamate, aspartate and alanine by undergoing partial oxidation in the TCA cycle to carbon dioxide, aspartate, alanine and lactate in a process called glutaminolysis (Reference Curi, Newsholme and Marzuca-Nassr3)

doi: 10.17219/acem/67222 191 HuSRaymanMP

The resultant 11-hydroperoxyeicosatrienoic acid (11-HPETE) spontaneously degrades to 11-hydroperoxydienoic acid (11-HPODE) and the (Z)-non-3-enal, which is then catalytically converted to 4HNE by cytochrome p450 isozyme CYP2E6 (and others)

Positive vWF staining in the GSH-treated group confirmed the occurrence of vascular lumens, whereas the scattered vWF fluorescence in the control group demonstrated limited angiogenesis (Fig