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Assessments Biomarkers of exposure included plasma cotinine [pre-registered primary outcome, measured at the end of the randomized phase], exhaled carbon monoxide, urinary total NNAL, GSSP:GSH (Ratio of Glutathione to Oxidized Glutathione) and 1-hydroxypyrene

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Fire was always a threat, and you could count on one or two barns burning every year

The value of rice-growing land increased in the flourishing economy, and by the 18 th century suitable land was much more difficult to come by