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Olea europaea is rich with polyphenolic compounds such as oleacin, oleuropein and hydroxytyrosol that mediate keap-1 degradation and Nrf2 release (Zhou et al., 2019)

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If you use both types of actives, apply them at different times of the day

Because the hinge and latch hypothesis predicts that the wild-type-mutant heterodimer does not support Nrf2 ubiquitination, a heterozygous missense mutation would result in the 75% reduction of Keap1 activity