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Pioneering studies have also suggested that during proinflammatory immune responses, most immune cells switch toward enhanced glycolysis and the pentose phosphate pathway to facilitate the activation and differentiation status increasing cytosolic and mitochondrial ROS production plays a vital role in metabolic reprogramming (Kelly and ONeill, 2015

Dihexa induces spinogenesis in cultured hippocampal neurons Actin-enriched spines increased in number in response to both dihexa (Figure 38B&D) and Nle'-AnglV (Figure 38C&D) following 5 days of treatment at 10 "12 M concentration that started on the 7 th day in vitro (DIV7) the results revealed a near 3-fold increase in the number of spines stimulated by dihexa and greater than 2-fold increase for Nle f -AngIV