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and the Open Fund Project of the Yunnan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease Prevention and Treatment (YPKLS2025-007, YPKLS2024-006, 2019DG016)

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Larger peptides with higher molecular weights, such as IGF-1 LR3 (MW 9,111.6 g/mol) or MOTS-c (MW 2,396.8 g/mol), require particularly stringent storage conditions due to their structural complexity

162 Furthermore, S1PR inhibits extrathymic and innate Treg cell production while driving Th1 development in a reciprocal manner, which is reciprocally regulated by S1P1-mTOR and the opposing TGF--Smad3 signaling