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Cirilo, M., Coccia, M.E., Attanasio, M and Fatini, C

A meta-analysis of randomized-controlled trials

When glutathione levels are high, it can interfere with this enzyme's ability to produce eumelanin (the dark pigment) and may encourage the production of pheomelanin (the lighter pigment)

A randomized, double-blinded, controlled phase III study in patients with stage IV chemotherapy-nave melanoma revealed a significant improvement in progression-free survival for ES in combination with paclitaxel versus paclitaxel alone in the subgroup of patients with normal baseline lactate dehydrogenase levels [118]