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This condition differs from tolerance, which is the need for increasing doses of opioids to maintain a defined effect (see Dependence)

doi: 10.3748/wjg.v28.i26.3071 75 SundaramVBjornssonES

Second, studies should establish clear "formula or herb, chemical basis, exposure, and effect" causal chains by integrating chemical profiling and batch-to-batch quality control with pharmacokinetics, tissue exposure, and pharmacodynamic responses at barrier sites, thereby identifying marker compounds and bioavailable fractions that best explain in vivo barrier outcomes