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-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species

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doi: 10.1038/s42255-022-00536-6 310

Cells were treated with different concentrations (from 1 to 1000 M) of a NO synthesis inhibitorL-NAMEduring different times (12, 24, 48, 72, 96, and 120 h), with and without retreatment every 24 h (retreatment was applied to approximate this in vitro model to the chronic exposure that occurs in vivo)