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The activity of phenformin needs to be characterized in further detail in vitro as well as in vivo prior to upcoming clinical trials

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Glutathione (in its reduced form) is a naturally produced, internal antioxidant that plays a key role in liver function and cellular health.* Glutathione is produced in the cells from the amino acids, cysteine, glutamic acid and glycine

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nevertheless an augmentation of the latter was related to more frequent pain (Saulnier et al., 2011)

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For missing values, the imputation method of median values for both groups was used

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