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Melittin, a primary bee venom allergen, is a potent inducer of acute pain ( Melittin activates the transient receptor potential vanilloid 1 (TRPV1) channel, a nonselective cation channel in peripheral sensory neurons, contributing to pain ( Another critical effect of venom components, particularly allergens, is hemorrhage

With a two-compartment open model with IV injection and first order elimination, the model assumes the body acts as two compartments: the central compartment (blood and highly vascularized tissues) and a peripheral compartment (less vascularized tissues)

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Benefits: -With cooling ZEROIL controls oil for up to 8 hrs and leaves skin feeling cool and refreshed