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Vitamin B 12 can be converted to coenzyme B 12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate

doi:10.1007/s12291-010-0042-x

For example, one review analysis of 12 studies found that research participants who took an ALA supplement lost about 1.5 pounds more during the study periods (which averaged 14 weeks) than those who got placebos