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However, not all individuals produce UroA efficiently owing to variations in gut microbiome composition, which has led to the development of direct supplementation strategies to achieve consistent levels across different populations (Reference Singh, DAmico and Andreux11)

Another study claimed that antioxidants treatment promotes lung cancer by endorsing cell proliferation via decreasing ROS level, DNA damage and inactivation of p53 gene expression [14]

Focused low-intensity pulsed ultrasound promotes autophagosome-lysosome fusion via the phosphoglycerate mutase family member 5 (PGAM5)/FUN14 domain containing 1 (FUNDC1) pathway, increasing the LC3-II/LC3-I ratio in chondrocytes (104)

nevertheless, there is still a dearth of solid human clinical evidence