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— Andrew

PGC-1 is a transcriptional coactivator that interacts with several transcription factors to control the transcription of more than 150 genes encoding mitochondrial proteins involved in fatty acid oxidation, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), the mitochondrial ribosomal machinery and membrane transport

Hyperuricemia remodels the serum proteome toward a higher inflammatory state

Numerous studies and clinical trials indicate loss of more than 5% of baseline body weight can reduce liver fat, and weight loss of 7% or more can reverse inflammation and fibrosis

Transcriptional control of energy metabolism by nuclear receptors