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Recent technological advances, such as specific targeted delivery systems and geneediting strategies, offer promising avenues for the spatiotemporal ATFtargeting interventions in macrophages, which is critical for improving therapeutic efficacy and safety

The abnormalities in lipid metabolism occur in 51-68% of cases, as evidenced by elevated triglycerides (TG) and low-density lipoproteins (LDL-C) levels and low high-density lipoproteins (HDL-C) levels (3, 4)