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Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders

111 A remaining question is whether potential controlling factors including allosteric control of glycogen synthase (GS) and phosphorylases via glucose-6-phosphate (G6P), 112 in addition to the insulin-independent transport of glucose across the hepatocellular plasma membrane by GLUT2 (as a glucose-sensitive protein in liver cells), can impact hepatic glycogen metabolism

However, the brain must still be aware of the state of the body so as to precisely coordinate activities that restore homeostasis

Note: Herbal supplements arent regulated as strictly as prescription medications, so their contents can vary widely