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Notably, CKs fostered the synthesis of sterols, particularly sitosterol, pivotal for cell proliferation and structure of membranes which are strongly disrupted under the action of BAP and 2iP possibly via pathway related to phospholipase D and lipoxygenase which were upregulated

A promising phase I clinical trial using cotreatment of trientine (a copper chelator) and carboplatin has shown CTR1-mediated higher cisplatin uptake and better outcomes [329, 330]