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This aspect is of particular interest for research on metabolic disorders and energy balance

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Evidence Boundary Not supported by published human clinical trial data for dosing, absorption, or efficacy

5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids