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It is associated with metabolic disorders such as weight loss, hypermetabolism and hyperlipidemia ( Several factors have been identified related to the pathogenesis of ALS: OS, mitochondrial dysfunction, neuroinflammation, excitotoxicity due to an increase in the neurotransmitter glutamate, defect in axonal transmission and in the metabolism of RNA, apoptosis, cytoskeletal abnormalities, disruption of membrane trafficking, endoplasmic reticulum stress, protein misfolding and aggregation (Papadimitriou et al., 2010

Staging The extent of the cancer is determined by tumor size, whether cancer cells have spread to nearby lymph nodes, and whether additional metastatic events have occurred