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Lewin E, Garfia B, Almaden Y, Rodriguez M, Olgaard K

REDEFINE-4: head-to-head vs tirzepatide Design: 800 adults with obesity, CagriSema vs tirzepatide 15 mg (the max Zepbound dose), for 84 weeks

When the gut barrier breaks down, the brain barrier can follow suit and vice versa

Environmental triggers induce mucosal stress, leading to protein citrullination, antigen presentation by dendritic cells, and subsequent autoimmune activation