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Additionally, biomimetic nanoparticles can exploit natural cellular uptake mechanisms, such as receptor-mediated endocytosis, to facilitate intracellular drug delivery and enhance therapeutic payload delivery to the desired site of action [276,277]

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After ischemia, TLR4 can be activated by factors such as HMGB1 (one of the DAMPs mentioned earlier), TNF-, and IL-1

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PA induces ferroptosis in H9c2 cardiomyoblasts in a time- and dose-dependent manner

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For instance, one randomized controlled trial reported a 68% improvement in migraine severity scores after three months of supplementation

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