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in addition, GSH becomes not just an inhibitor of inflammation but a regulator of innate immunity in a direction that benefits the host (134)

J Clin Invest 34:622628 McKhann GM, Tower DB (1961) Ammonia toxicity and cerebral oxidative metabolism

Critically, acute AMPK activation during ATP depletion exacerbates glycolytic overdrive and FAO, while chronic mTORC1 signaling in surviving neurons drives maladaptive lipid synthesis that fuels ferroptosis [111]