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"Epidemiology and outcomes of primary sclerosing cholangitis: an Australian multicentre retrospective cohort study"

27 In general, patients with an irreversible cause should be treated indefinitely, whereas those with a reversible cause should be treated until the deficiency is corrected and symptoms resolve

If the next scheduled dose is almost due, just skip the one you missed and carry on as usual never stack two doses to catch up

But it does restore the appropriate setting for those questions to be answered: physician-supervised clinical practice, pharmacy-grade compounding, and longitudinal patient monitoring