glutathione adducts quercetin Frontiers Quercetin Glycosides - an overview

H., Nepovimova, E., Kuca, K., et al

As far as MCFG resistance is concerned, from our data a role of glutathione metabolism in supporting this condition is not evident

R This pathway is the primary defense against: Aflatoxin B1 (a carcinogenic mycotoxin produced by Aspergillus) Cadmium Epoxides (reactive Phase I intermediates from polycyclic aromatic hydrocarbons) Lipid peroxidation products (4-hydroxynonenal, malondialdehyde) Mercury (organic and inorganic forms) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) GSTs exist in three locations: cytosolic (the largest class, with alpha, mu, pi, theta, sigma, omega, and zeta subfamilies), mitochondrial (kappa class), and microsomal (MAPEG family)

Ferroptosis is also frequently associated with metabolic diseases, with diabetes being a typical example