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While compelling evidence establishes ferroptosis as a key driver of cyst progression in ADPKDlinked to PKD1/PKD2 mutations, disrupted antioxidant networks (GPX4/SLC7A11), iron overload, and lipid peroxidationand validates ferroptosis modulators as potential therapeutics, several critical, insufficiently addressed research gaps persist

[5] Extracellular Matrix (ECM) Remodeling Research Studies examine: Matrix metalloproteinase activity and expression in fibroblast cultures Fibroblast migration, phenotype switching, and collagen synthesis pathways ERK/Akt/FAK signaling interactions with EGR-1-linked transcription Collagen organization and deposition mechanisms in tissue culture models ECM structural protein research in cellular repair systems Research investigates collagen organization processes and structural architecture development in controlled laboratory models

10.1074/jbc.273.37.23629 Biol