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Ghrelin levels increased at night in the lean controls but did not in the obese group (481)

As such, preserving circadian integrity emerges as a strategic target in precision geromedicine, not only to mitigate systemic aging but also to tailor pharmacological treatments

For example, it appears to switch cardiomyocyte energy production from glucose utilization to fatty acid oxidation in mice, dependent on UCP2 induction (282)