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1988 Oct 18;155(3):247-53

MTX also boosts the release of adenosine, a highly anti-inflammatory chemical that is found in all human cells

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The SREBP-1 protein is also post-translationally activated by long-chain ceramides, which decrease INSIG-1 expression in an ER stress-dependent manner to promote SREBP-1 cleavage and maturation (73)