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Vyunova T, Andreeva L, Shevchenko K, Myasoedov N: Peptide-based anxiolytics: The molecular aspects of heptapeptide selank biological activity

Contraindications This therapy may not be suitable for individuals who: Are pregnant or breastfeeding Have active malignancies or tumor-related conditions Have uncontrolled metabolic or endocrine disorders Are under 18 years of age A consultation is required prior to treatment

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Similarly, co-culturing IGF-I / osteoclast precursors, with IGF-I +/+ osteoblast precursors, also produces less (by 50%) multi-nucleated osteoclasts than co-culturing IGF-I +/+ osteoclast precursors with IGF-I +/+ osteoblasts (65), suggesting that the expression of IGF-I in osteoclast precursors is also required to support the full-scale osteoclastogenesis