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Proc Natl Acad Sci 107(11):51125117 Juarez JC et al (2002) Histidine-proline-rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain

59,60 Structural changes within GPCRs facilitate their function as molecular conduits that transmit extracellular signals across membranes to elicit cellular responses

Important Safety Information Metformin is a prescription medicine that is FDA approved to treat Type 2 diabetes mellitus when hyperglycemia cannot be managed with diet and exercise alone