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This network includes the up-regulation of ribosome biogenesis genes (e.g., AmRPL5 , AmGNBP1 ), chloroplast- and peroxisome-associated genes (e.g., AmISD1 , AmID1 ), and secondary metabolic genes (e.g., AmAGBE3 , AmPCT2 )

In addition, DOT1L is the only histone lysine methyltransferase responsible for H3K79 methylation which can promote the occurrence of leukemia

This review summarizes recent advances in understanding the role of flavonoids in regulating immune cells and their therapeutic application in inflammatory diseases