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As various matrix metalloproteinases are involved in the degradation of collagen and elastin, inhibition of these enzymes represents another strategy to prevent extracellular matrix breakdown and its influence on skin aging

Lifelong endurance training (more than 3 times/week) lower DNA methylation in 714 gene promoters, including those associated with glycolysis, glycogen metabolism, muscular dystrophies, and oxidative stress response in skeletal muscle of the elderly, potentially enhancing the expression of genes involved in muscle metabolism and myogenesis, while the methylation levels of introns, CpG islands and exons appear similar between physically active and inactive groups [132]

Maes M, Crespo Yanguas S, Willebrords J, Weemhoff JL, da Silva TC, Decrock E, Lebofsky M, Pereira IVA, Leybaert L, Farhood A, Jaeschke H, Cogliati B, Vinken M