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Pros, Cons, and Who They're Best For Pros: Highest clinical success rates of any cessation method (varenicline has a 33% quit rate at 6 months according to Cochrane reviews [9]), no nicotine intake, addresses the neurochemical root of addiction Cons: Requires doctor's prescription, potential side effects (nausea, vivid dreams, mood changes), not suitable for everyone, supply issues in some regions Best for: Heavy, long-term nicotine users who've tried other methods without success, and those with strong physical dependence 8

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