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Description

A recent pilot infusion study in two healthy adults reported no adverse effects up to 20 mg

L-Nle was preferred in the N-terminal for optimal inhibition and zinc coordination to the oxygen of the benzamide function is estimated to allow the lipophilic P1 substituent to be easily accommodated in the S1 pocket

Fluorescence measurements are in agreement with the position of the N-morpholino-ethansulfonic acid, close to Trp28, identifying a possible ligandin-substrate binding site