acetaminophen toxicity glutathione depletion Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90-95% gets broken down safely by glucuronidation + sulfation → non-toxic stuff you pee out. *The problem Pharmacology 401 k Paracetamol NAPQI
Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine The multiple mechanisms and modes of cell death after acetaminophen overdose A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Acetaminophen Pathway (toxic doses), Pharmacokinetics
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