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Inhibitors of ferroptosis, such as Fer-1, D-mannose, and icariin, may mitigate the pathological processes of OA by suppressing ferroptosis in chondrocytes

To mechanistically determine whether 15LO1 pathway activation alters the intracellular redox balance, particularly under T2 conditions, these ex vivo findings were modeled in vitro in primary HAECs

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Our analysis revealed a positive correlation between the NF-B pathway and EAAT3 expression in the KP model (Supplementary Fig