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Failure to enforce a provision is not a waiver

B12 shots are used to treat and support many conditions, including: B12 Shots for Weight Loss While a balanced diet and consistent physical activity are still the best ways to lose weight, studies find that B12 injections can increase fat metabolism and improve insulin resistance, especially in those who are B12-deficient

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Its generally advised that you be up to date on your vaccines before starting methotrexate, so ask your doctor about this