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Description

Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells

High concentrations appear in wound fluid, blood platelets, and areas of active tissue remodeling

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AbbVies twin-star pipeline includes Telisotuzumab vedotin (ABBV-399) and Telisotuzumab adizutecan (ABBV-400), both based on the ABT-700 antibody and conjugated with MMAE (a microtubule inhibitor) and adizutecan (a topoisomerase I inhibitor), respectively