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Oxidative stress mediates collateral sensitivity to tamoxifen Earlier reports have shown that heightened P-gp ATPase leads to selective decrease in cellular ATP level and a rise in reactive oxygen species (ROS), likely due to higher electron leak from mETC though enhanced oxidative phosphorylation [15, 16]

Recent studies have combined neuroimaging with peripheral measures of oxidative stress (e.g., lipid peroxidation markers) and neuroinflammation (e.g., pro-inflammatory cytokines) to establish mechanistic links between ethanols molecular effects and behavioral outcomes

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miRNAs as Biomarkers and Therapeutic Targets A notable feature of miRNAs is their remarkable stability in human body fluids (plasma, serum, and cerebrospinal fluid), largely due to their association with extracellular vesicles or RNA-binding proteins that protect them from degradation (Burlacu et al