MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 1 SMILES ClC1=CC(Cl)=C(C=C1)C(=O)NS(=O)(=O)C1=CC=C(Br)S1 Purity (HPLC)

1 SMILES ClC1=CC(Cl)=C(C=C1)C(=O)NS(=O)(=O)C1=CC=C(Br)S1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Product Name Pomalidomide-CO-C4-alkyne Synonyms Pomalidomide-4'-CO-C4-alkyne CAS Number n/a Related CAS Molecular Formula C20H19N3O5 Molecular Weight 381

1038/nature13527

CA-SS-Lissamine Rhodamine B is a cleavable HaloTag ligand featuring a disulfide bond that can be cleaved using a reducing agent

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 1 SMILES ClC1=CC(Cl)=C(C=C1)C(=O)NS(=O)(=O)C1=CC=C(Br)S1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,