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We recently showed that mouse periportal assembloids model key architectural features of the in vivo tissue and can serve as a tractable in vitro model to investigate universal principles of bile canaliculi formation, cholestatic injury or fibrogenesis 51

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These extremely low GA infants may not have surfactant deficiency or RDS but instead have early requirements for oxygen and ventilatory support due to multiple factors leading to respiratory instability of prematurity 127,128,129