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Drug metabolism involves the chemical biotransformation of parent drugs molecules, commonly through phase I reactions (catalyzed by CYP450 and FMO enzymes) and phase II reactions (involving conjugation reactions driven by UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases and methyltransferases), leading to more hydrophilic, usually inactive compounds, that are more readily excreted from the liver into urine and feces ( Hence, one way to monitor the harmful effects of a xenobiotic on hepatocytes is by examining the intracellular metabolome

doi: 10.1016/j.freeradbiomed.2019.12.026 72 WangDPengYXieYZhouBSunXKangRet al

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Osteosarcoma stem cells resist chemotherapy by maintaining mitochondrial dynamic stability via DRP1