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This innovative technique has revealed that the solid stress imposed on murine breast tumors is ~ 2 kPa, a magnitude 5 to 8 times higher than the stress that individual cancer cells sense within the primary tumor [116]

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A study in rodent models demonstrated that administration of a selective LAT1 inhibitor led to decreased plasma BCAA levels, enhanced insulin-stimulated glucose uptake in skeletal muscle, and ultimately, improved glycemic control (149)