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In mitochondria, GSH regulates apoptosis via modulation of oxidative phosphorylation and cytochrome c activity

Fazzari M, Trostchansky A, Schopfer FJ, Salvatore SR, Snchez-Calvo B, Vitturi D, Valderrama R, Barroso JB, Radi R, Freeman BA, Rubbo H (2014) Olives and olive oil are sources of electrophilic fatty acid nitroalkenes

For instance, chronic doxorubicin (DOX) intervention can also lead to cardiomyocyte aging, suggesting that the aging mechanism shares many irreversible stress factors with the cardiac injury pathway, such as decreased Sirtuins expression, increased p38 mitogen-activated protein kinases (p38MAPK) signaling, and decreased antioxidant enzyme levels represented by MnSOD [21, 22]

Several factors, such as oxidative stress, dysregulation of adipocytokines, the inflammasome, anti-inflammatory modulators like secretoglobin and IL-37, and the presence of other comorbidities inducing systemic inflammation may contribute to the development of inflammatory conditions in individuals with asthma and obesity