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However, it differs from other forms of PCD in that ferroptosis is based on divalent iron and leads to cell death by promoting lethal accumulation of intracellular lipid peroxides [12]

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indeed implicate brain PPAR 2 among the mechanisms by which the KD reduces seizures ( in vivo treatment of rats with a KD increased hippocampal catalase mRNA and protein and that this upregulation required PPAR 2 ( PPAR 2 activation and that catalase may contribute to the antiseizure efficacy of the KD