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Several natural products have been reported to induce ferroptosis by inhibiting GPX4, such as Capsaicin (27), heteronemin (28) and Eriocitrin (29) ( Figure 3 )

reported that persulfidation of Cys136 in rat CSE suppresses its -lyase activity to generate CysSSH from cystine ( -lyase activity to generate H 2 S from cysteine ( 2 S or CysSSH