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Abbreviations CNS Central nervous system BDNF brain-derived neurotrophic factor CSF cerebrospinal fluid AD Alzheimers disease D H dopamine -hydroxylase A amyloid- APP amyloid precursor protein AA ascorbic acid AGEs advanced glycation end products RAGE receptors for AGE BBB blood brain barrier LRP-1 low-density lipoprotein receptor-1 GSH glutathione SSRIs selective serotonin reuptake inhibitors 4-HNE 4-hydroxynonenal MCI mild cognitive impairment ROS reactive oxygen species CDR Clinical Dementia Rating HPA hypothalamicpituitaryadrenal MMSE Mini-Mental State Examination CI confidence interval IQR inter-quartile range SMD standard mean deviation

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For example, it was added to dithranol and methotrexate in topical treatment of psoriasis Agarwal and colleagues, Javadzadeh and Hamishehkar

(2021) Efficiency of the sublingual route in treating B12 deficiency in infants