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In addition, an extended ZSWIM8 loop within HEAT-repeat 3 anchors the MID domain, primarily through a phenylalanine (F1261) inserted into an exposed hydrophobic cavity of the MID domain

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Significant increases in cellular GSH level were detected in cultures grown at 100 g/ml or 150 g/ml 5-FOA, but not at 50 g/ml 5-FOA (Figure S2A)

The ablation of OPLAH in mouse models has led to an accumulation of 5-OP, which results in oxidative stress, fibrosis, and the continued elevation of pressure due to heart failure [125]