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As MOTS-c activates AMPK and NRF2, it also indirectly suppresses the mTOR (mechanistic target of rapamycin) pathway, the master growth and anabolism regulator that, when chronically overactivated, accelerates the accumulation of senescent cells

Current areas of scientific investigation include cytoskeletal signaling pathway analysis, extracellular matrix interaction studies, peptide signaling coordination research, cellular mobility and organization investigations, multi-pathway signaling research, and peptide interaction and pathway convergence studies

A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways