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Lose weight without a GLP-1: Depending on your other symptoms, you may want to consider hormone therapy

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REDEFINE 4: The Tirzepatide Test The results that attracted the greatest market attention came from REDEFINE 4, an 84-week open-label Phase 3 trial reported in February 2026, in which CagriSema was pitted directly against tirzepatide 15 mg, the highest approved dose of Eli Lillys Zepbound

This is when GI effects are most pronounced, and heavy meals are most likely to trigger nausea