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This systems-level perspective underscores that the therapeutic potential of exercise mimetics lies not in reproducing the full complexity of exercise itself, but rather in selectively harnessing specific, biologically actionable components of exercise-induced adaptation

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Omics platforms, including single-cell level analyses such as single-cell RNA sequencing (scRNA-seq), provide deep insights into -cell heterogeneity, revealing distinct functional subpopulations that differ in maturity, metabolic activity, and susceptibility to external stressors such as inflammation, glucotoxicity, and the endoplasmic reticulum (ER) stress they mediate

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